This antibody labels the Bcl-2 protein in the cytoplasm of B-cells in mantle zones, interfollicular T-cell areas, and a few cells in the germinal centers of lymphoid tissues and basal cells of epithelial tissues; it can stain both normal and neoplastic cells. It is a useful tool for identifying follicular lymphomas, diffuse large cell lymphomas, and differentiating follicular lymphomas from reactive lymph nodes when used in a panel of antibodies.