This antibody labels CD30 protein on the membrane and cytoplasm of scattered large activated B- and T-lymphocytes of tonsil, lymph nodes, the spleen and thymus in both normal and neoplastic tissue. The antibody labels the CD30 protein in normal and neoplastic cells, such as Hodgkin and Reed-Sternberg cells and anaplastic large-cell lymphoma cells (ALCL). CD30 positive staining may aid in identifying of classical Hodgkin’s lymphoma and ALCL when used in a panel of antibodies.