This antibody labels the CD68 protein on the cytoplasm of different types of macrophages of monocyte lineage, myeloid precursor cells in the bone marrow, some non-hemotopoietic tissues such as Kupffer cells in liver and cells in the renal glomeruli and tubules. It is a useful tool for classifying neoplasms of myeloid and macrophage/monocyte origin when used in a panel of antibodies.